Australia shines in clinical trial activity ranking but gaps revealed

An examination of how clinical trials have changed in Australia over the past 15 years has identified challenges such as lack of balance in the types of research, lack of collaboration among Australian researchers, and the importance of diversity of funding.

“Clinical trials are invaluable because they provide medical evidence that forms the foundation of many treatments and therapies we take for granted,” says lead researcher Dr Anna Lene Seidler from the NHMRC Clinical Trials Centre at the University of Sydney.

“Compared to other OECD countries, Australian activity for clinical trials can be considered ‘healthy’, but three is room for improvement.

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“Public funding is important to ensure diversity of trials, so there is a greater balance in the type of research that is supported, and to address crucial health questions that would otherwise be overlooked.”

“For instance, prevention research has an important place in clinical trials because it investigates how to stop a disease from developing. Prevention research is much more likely to be funded by public sources than by industry.”

The study, published inMedical Journal of Australia, was led by researchers from the NHMRC Clinical Trials Centre at the University of Sydney.

Researchers looked at clinical trials conducted in Australia between 2006 and 2020. The data was collected from the Australian New Zealand Clinical Trials Registry and, which captures 95 percent of registered trials in Australia.

Australian trials cover a wide variety of healthcare interventions. 45 percent are drug trials and there has been an increase in earlier phases of these trials.

An overwhelming proportion of clinical trials was focused on treatments (75 percent) compared to prevention (15 percent). Nearly half of these trials conducted in Australia had some industry involvement.

0.8 percent of trials had a specific focus on the health of First Nations Peoples.

Trials are also becoming smaller over time and the impact of this change on the overall success of a trial is being investigated by researchers at the NHMRC Clinical Trials Centre.

Australian research funding may not be keeping up with the burden of certain diseases in the country.

Many trial sponsors and scientists were reluctant to share data, which can result in research waste. Only 1 in 5 planned on sharing their data.

In the US, it is mandated that any National Institutes of Health (NIH) funded project needs to share data for certain types of studies. NIH is a large public funding body for trials in the US. However, in Australia, data sharing for clinical trials is not mandated by the Australian National Health and Medical Research Council (NHMRC), which is responsible for medical research and a major public funding body in the country.

Co-author Dr Melina Willson, Australian New Zealand Clinical Trials Registry Manager says there is now a national infrastructure, Health Data Australia, that helps a researcher to request access to data.

“Health Data Australia is important infrastructure that encourages sharing of data. Now we need policies from public funders, like the NHMRC, and commercial funders, and utilisation by the wider clinical trials research community to further its success. Australia could build on this momentum and be the model for co-ordinated action internationally.”


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