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Buprenorphine is a prescription approved by the Food and Drug Administration (FDA) that effectively treats opioid dependence or addiction. But women, as well as Black and Hispanic populations, do not have equal access to this potentially lifesaving medication, new Mayo Clinic research finds. The study published Friday, June 3, in JAMA Network Open.
The research team used the OptumLabs Data Warehouse to examine 3,110 filled prescriptions of buprenorphine from 72,055 emergency department visits across the U.S. from 2014 to 2020. While access to the medication increased over time for all groups studied, it was consistently lower for people 41 and older, women, and Black and Hispanic people. These disparities remained relatively steady over the years studied.
“The persistence of the disparities is frustrating. This is a truly lifesaving treatment. But it does appear that all groups are gaining access over time, which is what we want to see,” says Molly Jeffery, Ph.D., scientific director for Mayo Clinic’s Division of Emergency Medicine Research and the study’s senior author.
The researchers note that people with socioeconomic advantages — white, male or younger — were more likely to receive buprenorphine. “These findings are not surprising, given that patient- and system-level barriers for accessing buprenorphine often disproportionately impact vulnerable populations,” they write. They say that obstacles to receiving the drug include systemic racism, mistrust of health care professionals and the health care system, not enough clinicians able and prepared to prescribe buprenorphine in the emergency department, regulatory requirements, reimbursement issues, and addiction and mental health stigmas.
“The laws that currently limit access to buprenorphine are a legacy of an earlier opioid epidemic from literally 100 years ago. Those laws are based in mistrust of physicians and patients and a fundamental misunderstanding about substance use disorders,” Dr. Jeffery says. “Making it easy to access safe and effective treatment is the best way to fight the epidemic of opioid overdoses, which has gotten worse during the COVID-19 pandemic.”
The FDA approved buprenorphine to treat opioid use disorder in 2002. Since then, the National Institutes of Health points to several studies showing its efficacy in treating opioid addiction and thereby reducing opioid overdose deaths. A 2014 meta-analysis study showed that patients receiving buprenorphine were 1.82 times more likely to stay in treatment than those who received a placebo.
To Dr. Jeffery and her Mayo colleagues, the solution is simple: Get more physicians to prescribe buprenorphine.
“We know exactly what to do to close the gap: Get more health care providers, particularly primary care providers, involved in prescribing buprenorphine,” Dr. Jeffery says. “Mayo Clinic recognizes the importance of primary care access to buprenorphine, and our clinicians are addressing the disparity gap by prescribing buprenorphine whenever appropriate and providing it through a primary care program and an addiction clinic.”
Dr. Jeffery said another way to close the gap is to remove policy barriers, such as additional requirements for clinicians to prescribe buprenorphine beyond what’s needed for an opioid prescription. Policies like that “needlessly limit access to a safe and effective treatment and increase stigma,” she adds.
These findings also will be presented at the AcademyHealth Annual Research Meeting on Sunday, June 5, in Washington, D.C., by lead author Maria Stevens, a Mayo Clinic researcher and a Ph.D. candidate in Health Policy and Management at the University of North Carolina at Chapel Hill in the Gillings School of Global Public Health.
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