Wild birds are believed to be the reservoir of influenza A viruses, and poultry may serve as a key intermedia in the cross-species avian influenza virus (AIV) transmission from wild birds to human. The backyard poultry, especially those locating in the flyway of migratory birds, is supposed to play a vital role in the introduction of wild bird AIVs. A novel reassortant AIV, influenza A(H7N4), has been identified in such a scenario, according to a new study published by Science Bulletin.

According to the epidemiological and laboratory investigations, the novel H7N4 virus originated from wild bird AIVs, infected backyard chickens and ducks and cause a severe human infection. A comprehensive investigation has been conducted on this case, confirming the viral infection and the transmission route. Early identification and response to this incident interrupted the spread of this novel virus.

The patient developed severe pneumonia after preceding influenza like illness. She finally responded to treatment with oseltamivir and ICU support. Based on the genome sequencing, the accountable novel virus is distinct from previously-reported avian H7N4 and H7N9 viruses. It is low pathogenic to avian, susceptible to antivirals and has binding preference of avian-like α2, 3-linked sialic acid receptor.

The symptomatic surveillance system and pathogen detection platform, including next generation sequencing, established in Jiangsu Provincial CDC play an important role in the early identification and early intervention on novel influenza viruses which could infect human.

“Threats from AIVs never stop. For early warning and preparedness regarding influenza pandemic, it is important to keep alert on the AIV infection of backyard poultry and feeders,” the authors conclude.

IMAGE SOURCE: Creative Commons

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