New drug application doubles rates of remission in patients with Ulcerative Colitis

A new drug, investigated by Amsterdam UMC together with colleagues around the world, is effective as a treatment against ulcerative colitis. With the clinical trial demonstrating a doubling in the rates of remission, to up to 50%, in certain groups. The results of this clinical trial are, today, published in the New England Journal of Medicine.

Around the world, it is estimated that millions live with ulcerative colitis, a condition that is only growing in prevalence. Geert D’Haens, lead author and Professor of Gastroenterology at Amsterdam UMC, says “there is still a high unmet need for safe and effective treatments for ulcerative colitis. This new medicine meets this need for an important proportion of patients”

Ulcerative colitis is a common chronic disease of the colon. Patients have bloody diarrhea, abdominal pain, anemia and fatigue. Many patients have an impaired quality of life and current treatments cannot always control the disease. In that case, patients need to undergo surgery (colectomy) with a stoma or a pouch-construction. Chronic inflammation of the colon is also associated with an increased risk of cancer.

If you enjoy the content we create and would like to support us, please consider becoming a patron on Patreon! By joining our community, you’ll gain access to exclusive perks such as early access to our latest content, behind-the-scenes updates, and the ability to submit questions and suggest topics for us to cover. Your support will enable us to continue creating high-quality content and reach a wider audience.

Join us on Patreon today and let’s work together to create more amazing content!

Researchers identified Interleukin-23 as a very important protein in triggering and maintaining gut inflammation, both in Crohn’s disease and ulcerative colitis and also in the chronic skin disease psoriasis. Previously it has been shown that blocking interleukin-23 with specific therapeutic antibodies is highly effective for those with psoriasis and Crohn’s disease. Mirikizumab is the first such antibody that was tested for ulcerative colitis. 

Clinical Trial 
In recent years, a large group of researchers from around the globe performed two Phase 3 clinical trials to assess the safety and efficacy of mirikizumab in 1281 adult ulcerative colitis patients with moderate to severe inflammation. For comparison, a “control group” of comparable ulcerative colitis patients was not treated with mirikizumab but with a placebo. Patients received 300 mg mirikizumab or placebo (in a 3:1 ratio) via an infusion every 4 weeks for 12 weeks in total (LUCENT-1 study). If patients responded to mirikizumab in these 12 weeks (544 out of 1281 patients), they continued in the LUCENT-2 study where they received 200mg mirikizumab or placebo (in a 2:1 ratio) via an injection every 4 weeks for 40 additional weeks. 

Little to no side effects 
Patients who were treated with mirikizumab were more likely to achieve clinical remission at both the end of the LUCENT-1 and LUCENT-2 than patients treated with placebo (LUCENT-1 24.2% versus 13.3% and LUCENT-2 49.9% versus 25.1%). The patients that received mirikizumab also had higher clinical response, endoscopic remission, and less bowel movement urgency. Interestingly, mirikizumab treatment appeared very safe. Adverse events were not more common with mirikizumab than with placebo treatment. 

“If we combine these results together, we see that mirkizumab is an effective drug for those patients with moderately severe and severe forms of ulcerative colitis. We hope that it will be available as a treatment option in Europe this year,” concludes D’Haens. 


ON SALE! Charles Darwin Signature T-shirt – “I think.” Two words that changed science and the world, scribbled tantalizingly in Darwin’s Transmutation Notebooks.

Success! You're on the list.

THE ABSTRACT: “Nothing Special” skillfully deconstructs the shimmering veneer of the iconic art world.
In the shadowy realms of 1960s New York City, Nicole Flattery introduces …
DAILY DOSE: Nobels in Physics and Medicine handed out; Stoneman Willie gets his due.
NOBEL PRIZE IN PHYSICS AWARDED. The 2023 Nobel Prize in Physics was …

Leave a Reply

%d bloggers like this: