Metal shows its steel against fungal infections


Join us in The Bullpen, where the members of the Scientific Inquirer community get to shape the site’s editorial decision making. We’ll be discussing people and companies to profile on the site. On Wednesday, October 12 at 5:30pm EST, join us on Discord and let’s build the best Scientific Inquirer possible.

University of Queensland researchers say metal compounds could be the answer to the growing problem of drug-resistant fungal infections.

Associate Professor Mark BlaskovichDr Alysha Elliott and other researchers from UQ’s Institute for Molecular Bioscience, together with Dr Angelo Frei from The University of Bern in Switzerland led a group of collaborators which found one in five metal compounds analysed displayed antifungal properties.

Dr Blaskovich said the compounds, a particular class of molecule, showed potential to be used in the development of much-needed antifungal drugs.

ON SALE! Charles Darwin Signature T-shirt – “I think.” Two words that changed science and the world, scribbled tantalizingly in Darwin’s Transmutation Notebooks.

“Fungal infections cause an estimated 1.5 million deaths a year and are especially dangerous for people who are immunocompromised, such as chemotherapy and transplant patients,” Dr Blaskovich said.

“As well as bacteria becoming resistant to antibiotics, fungi – which cause meningitis and infections of the skin, lungs and bloodstream – are becoming resistant to known treatments.

“There are only 10 antifungal drugs in various phases of clinical development at the moment and not all of them will pass trials to make it to patients, so we urgently need more options.”

The team had previously shown metal compounds, like the platinum-containing anticancer agent cisplatin have antibacterial properties, so carried out the first large-scale screening to investigate their antifungal potential.

“We found 21 per cent of the metal compounds screened showed antifungal activity – compared to only 1 per cent of the 300,000 non-metal compounds screened previously,” Dr Blaskovich said.

“Encouragingly, those with the highest antifungal activity also showed low toxicity in preliminary tests.

“The beauty of metal complexes is their three-dimensional structure, meaning they could work in different ways to existing antifungal drugs and overcome resistance.”

Dr Blaskovich is co-founder of Community for Open Antimicrobial Drug Discovery (CO-ADD), which collected the compounds and conducted the initial screening for this study.

“CO-ADD offers free testing of new compounds from research groups around the world, as well as a searchable database to accelerate the discovery of antibiotics and antifungal drugs,” he said.

“We’d like to see more researchers submit their metal complexes for antimicrobial testing so we can speed up the pipeline to produce new antifungal drugs and prevent a resistance crisis.”


Success! You're on the list.

Resolving a seeming contradiction, study advances understanding of visual recognition memory
Because figuring out what is new and what is familiar in what …
Blocking abnormal stem cell signal during aging lessens related bone loss
A cellular signal essential to the development of the skeleton increases during …

1 comment

Leave a Reply

%d bloggers like this: