Uncovering the mechanism driving a global health threat.

The World Health Organisation calls antimicrobial resistance (AMR) “one of the most urgent health threats of our time” and now, thanks to a collaboration between the Hudson Institute of Medical Research and the Wellcome Sanger Institute, Cambridge UK, for the first time we know how it spreads inside the human gut.

Exclusive Darwin Tree of Life (just think.) Sci-Tee only at Scientific Inquirer!

Lead researcher Dr Samuel Forster said resistance occurs when bacteria acquire changes and no longer respond to antibiotics. This makes infections harder to treat and increases the risk of disease spread, severe illness and death.

“Antibiotic resistance is emerging at an alarming level, rendering some bacterial infections untreatable and increasing dependence on last line antibiotics,” Dr Forster said.


Processing…
Success! You're on the list.

Emerging threat of antimicrobial resistance

“The gut microbiome contains thousands of beneficial bacterial species, each of which may carry antibiotic resistance genes and share these with disease causing bacteria,” he said. “This work provides a new tool in the toolkit for managing the emerging threat of antimicrobial resistance.”

Bacteria can develop resistance either through changes in their genetic sequence or by acquiring resistance genes from other bacteria. But resistance in pathogens is just one side of the story – the beneficial bacteria in our microbiomes so they also need ways to protect themselves, otherwise they will be destroyed every time we take antibiotics.

Understanding the diversity of resistance in the microbiome and which ones can be spread to pathogens allows us to be prepared and take actions to prevent this occurring.

Transfer from the microbiome to pathogens

“Our research provides world-first experimental identification of the key mediators of this transfer from the microbiome to pathogens.” said Dr Emily Gulliver, a postdoctoral researcher also working on the project.

“Of most concern, bacteria carrying these elements were also detected in other body sites including the vagina, skin and nasal cavity, with some also found across diverse environmental samples. This suggests how widespread these elements may be,” said Dr Gulliver.

Dr Forster believes the study of the human gut microbiome is delivering incredible results: “In this case we are discovering the rules that allow bacteria to share key functions between them and using this knowledge to reduce and prevent potentially deadly infections.”

IMAGE CREDIT: Hudson Institute of Medical Research


DAILY DOSE: Elon Musk trolls Wall Street; First Law of Thermodynamics violated in quantum systems?
NOT SO FAST. Tesla and SpaceX’s Elon Musk has a lot to …
DAILY DOSE: Monkeypox outbreak spreads across the world; Shanghai finally turns the corner.
Another disease outbreak is spreading across the globe on top of Covid-19 …
DAILY DOSE: Fear and loathing in North Korea; The sudden demise of a Mars rover.
FEAR AND LOATHING IN NORTH KOREA. North Korean Top Dog KJU has …
The role of variability: From playing tennis to learning language.
Variability is crucially important for learning new skills. Consider learning how to …

Leave a Reply

%d bloggers like this: